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. 2019 May 24;10:2315. doi: 10.1038/s41467-019-10266-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — CFC enhanced neuronal activity in the mPFC. a Left: experimental design of groups used to assess Fos expression. Home-cage (HC; n = 4), context exposure only (Ctx; n = 6), contextual fear conditioning (CFC; n = 6). Lightning bold indicates foot-shock (1US). Right: illustration of a coronal brain section indicating the mPFC region (red) where Fos⁺ neurons were analyzed. b Representative examples of Fos⁺ cells (green) in all groups. c Percentage of Fos⁺ cells in each group. One-way ANOVA F_(2,13) = 126.3, p < 0.0001. Post-hoc Bonferroni test: HC vs. Ctx *p < 0.0001, HC vs. CFC *p < 0.0001, Ctx vs. CFC *p = 0.032. Scale bar = 50 µm. Bar graph shows mean + s.e.m. Source data are provided as a Source Data file