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. 2019 May 24;9:7850. doi: 10.1038/s41598-019-43955-4

Figure 2.

Figure 2

Differences between WT and D3KO mice in response to 9 weeks of APD treatment. All graphs represent percent volume change over time per group. Curves for treatment group represented as follows: saline (SAL in red), haloperidol (HAL in blue) and clozapine (CLZ in green) for D3KO mice and WT littermates. (A) Total brain volume was not significantly affected by either HAL and CLZ relative to SAL in either WT or D3KO mice. (B) Prelimbic area volume was significantly increased in WT mice for CLZ treated relative to SAL mice (t = −2.335, p = 0.021; green asterix). Volume was reduced in D3KO mice at a trend level at 3 weeks (t = −2.098, p = 0.038) and significant at 6 weeks of treatment relative to SAL (this was not observed in WT mice; t = −2.544, p = 0.012, blue asterix). (C) HAL increased striatal volume in WT and D3KO mice relative to SAL (t = 2.623, p = 0.010; blue asterix). CLZ increased STR volume in WT mice relative to SAL (t = −2.004, p = 0.048; green asterix). (D) Hippocampal volume changes were not differentially affected by HAL or CLZ relative to SAL for either WT or D3KO mice. All significant three way interactions were decomposed by testing WT and D3KO mice separately, and Bonferroni corrected (corrected p < 0.025).