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. 2019 May 24;10:2307. doi: 10.1038/s41467-019-10290-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — In vivo examination of CDPE-Cs hydrogels against several controls. a Conventional gauze dressings, Curaspon®, Surgicel®, and CDPE and CDPE-Cs hydrogels were applied immediately after induction of the liver injury and absorption of the initial bleeding from the injury sites, to determine the total time to hemostasis in rats (n = 6 animals per group). For gauze dressings, bleeding did not stop until the end of experiments (600 s). b The total amount of blood loss, measured over 10 min, in rats (n = 6 animals per group). c Time to hemostasis for rabbits (n = 6 animals per group). d Blood loss in rabbits (n = 6 animals per group). e Time to hemostasis for pigs (n = 6 animals per group). f Blood loss in pigs (n = 6 animals per group). g The mean arterial pressure of the rabbits were monitored over 90 min, where the measurements over the first 30 min represent the mean arterial pressure of animals before induction of the liver injury (n = 3 animals per group). Box plots correspond to means (center line) ± SD (boundaries). Source data are provided as a Source Data file