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. 2018 Dec 26;176(12):1922–1931. doi: 10.1111/bph.14536

Figure 5.

Figure 5

Effect of P. gingivalis immunization on endothelial function. Mice were immunized with an i.p. injection of P. gingivalis formulated with alum and IL‐12 (Alum/PG/IL‐12) and are compared with control mice that received an i.p. injection of alum only (Alum). Six days after the second immunization, both groups received a 14 day infusion of low dose of Ang II infusion (0.25 mg·kg−1·day−1). Isolated aortic segments were studied after a 14 day Ang II infusion in organ chambers. Following preconstriction with 3 × 10−7 M of PGF2α, vasodilatation to increasing concentrations of ACh (A) and SNP (B) was recorded and analysed by repeated measures ANOVA.