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. 2018 May 22;176(12):1829–1838. doi: 10.1111/bph.14334

Figure 4.

Figure 4

Induction of renal HSP70 expression in rats immunized with HSP70. Normotensive Wistar Kyoto (WKY) rats immunized with injections of HSP70 and adjuvant in foot pads (ssWKY) received HSP70 gene or empty plasmid in both renal veins. Renal sections of rats untreated (A) and 72 h after delivery of HSP70 gene (B), demonstrating HSP70‐positive tubular areas. ssWKY rats developed immune cell infiltration (P < 0.001) in the kidneys after HSP70 gene delivery (C) and responded to a 4% sodium diet with an increase in BP (*P < 0.05) (D). †Immune cells in (C) are the sum of CD5+ and CD68+ (lymnphocytes and macrophages) cells. Figures made using data from Pons et al. (2013).