Figure 2.

S‐nitrosoglutathione (GSNO) specifically abolishes AT₁ receptor‐induced vasoconstriction. Specific AT₁ receptor‐induced vasoconstriction was assessed in response to angiotensin II (AngII) in the presence of PD123319 (a selective AT₂ receptor antagonist, 10⁻⁶ mol·L⁻¹) and compared to 5‐HT after exposure (30 min) to either physiological salt solution (control) or GSNO (2 x 10⁻⁶ mol·L⁻¹), followed by a 1‐hr washout. Changes in internal diameter (%) are expressed as means ± SEM. Two‐way ANOVAs (pretreatment, concentration) were used to calculate P values; *P < 0.05 versus control (Bonferroni post‐test)