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Antitumor efficacy using MPs to deliver TLR-3 agonists. TC-1 tumor cells were subcutaneously injected into C57BL/6 mice and treated. Three IP injections of PBS, soluble E7 peptide, chitosan particles (CH-NP) (empty), or chitosan encapsulated E7/Poly I:C particles (CH (E7+polyI:C)-NP) were administered once a week. a) Tumor volume and b) survival were measured over time. c) Tumors were harvested from each treatment group and imaged [94].
