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. 2018 Dec 18;176(12):2002–2014. doi: 10.1111/bph.14509

Figure 5.

Figure 5

Expression of markers of renal injury. Renal mRNA expression data of inflammatory markers at the end of the experiment are shown in Figure 5. Serpine1, Lcn2 and Ccl2 were significantly increased after renal ablation compared to controls, and no difference was found between the three groups. The cytokines defining TH17 and TH1 sub‐types, Il17a and Ifnγ, were significantly up‐regulated in wildtype mice. An increased expression for the master regulator of Treg cells, Foxp3 was found in wildtype and IL‐17A−/− mice. In addition, Il6 and Cxcl1 were significantly up‐regulated in all three genotypes after renal ablation. Number of mice examined was controls n = 6, wildtype n = 13, RAG‐1−/− n = 7, IL‐17A−/− n = 16. *P < 0.05, significantly different from control, # P < 0.05, significantly different from wildtype, § P < 0.05, significantly different from wildtype and IL‐17A−/−.