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. Author manuscript; available in PMC: 2019 May 25.
Published in final edited form as: Oncogene. 2016 Sep 19;36(10):1430–1439. doi: 10.1038/onc.2016.311

Figure 4. INO80 promotes the expression of lung cancer-associated genes.

Figure 4.

(A) Scatter plot showing the differentially expressed genes (DEGs) after Ino80 silencing. A549 cells were infected with NT or Ino80-shRNA viruses, and gene expression changes were determined by RNA-seq 4 days after virus infection. (B) RT-qPCR showing the down-regulation of genes important in lung cancer after Ino80 silencing. Gene expression was normalized to β-actin, and values were plotted as Mean ± SEM. (C) IPA showing the enrichment of cancer-associated genes in the down-regulated genes upon Ino80 silencing. Selected top categories are shown, and please see table S3 for the complete list. (D) IPA showing the predicted upstream regulators based on the down-regulated genes upon Ino80 silencing.