Table 1.
Patient and tumor characteristics
| Characteristics | Overall (n = 123) |
|---|---|
| Age (years), mean ± SD | 54.3 ± 7.6 |
| Sex, n (%) | |
| Man | 117 (95.1) |
| Woman | 6 (4.9) |
| ECOG performance status, n (%) | |
| 0 | 105 (85.4) |
| 1 | 18 (14.6) |
| Pathology, n (%) | |
| SCC | 120 (97.6) |
| Adenocarcinoma | 3 (2.4) |
| Location, n (%) | |
| Upper | 24 (19.5) |
| Middle | 59 (48.0) |
| Lower | 40 (32.5) |
| BMI (kg/m2), mean ± SD | 22.1 ± 3.3 |
| Histologic grade, n (%) | |
| Grade 1 | 12 (9.8) |
| Grade 2 | 88 (71.5) |
| Grade 3 | 23 (18.7) |
| Smoking, n (%) | |
| No (never smoked or quitted) | 7 (5.7) |
| Yes (current smoker) | 116 (94.3) |
| Clinical T stage, n (%) | |
| cT1 | 1 (0.8) |
| cT2 | 36 (29.3) |
| cT3 | 80 (65.0) |
| cT4a | 6 (4.9) |
| Clinical N stage, n (%) | |
| cN0 | 14 (11.4) |
| cN1 | 57 (46.3) |
| cN2 | 39 (31.7) |
| cN3 | 13 (10.6) |
| cTNM stage, n (%) | |
| II | 31 (25.2) |
| III | 92 (74.8) |
| Gross tumor volume (ml), mean ± SD | 100.9 ± 73.2 |
| Radiation dose (Gy), median (IQR) | 44.0 (43.2–45.0) |
| 40–44 Gy, n(%) | 62 (50.4) |
| 45–50.4 Gy, n(%) | 61 (49.6) |
| Target volume (ml), mean ± SD | 527.6 ± 228.5 |
| Dose-volume of lunga (%), mean ± SD | |
| V5 | 74.0 ± 21.2 |
| V20 | 20.8 ± 6.4 |
| Mean heart dose (Gy), mean ± SD | 18.3 ± 7.6 |
Abbreviations: BMI body mass index, ECOG Eastern Cooperative Oncology Group, IQR interquartile range, SCC squamous cell carcinoma, SD standard deviation
aVx = volume (mL) of lung receiving X Gy or more