Table 3.
Association between quartiles of adiponectin with metabolic syndrome risk score and its individual components, ERICA 2013–2014
| Clinical outcomes | Quartiles of adiponectin | p for trends | ||||||
|---|---|---|---|---|---|---|---|---|
| First (n = 1092) | Second (n = 1101) | Third (n = 1112) | Fourth (n = 1241)b | |||||
| β (95% CI) | ||||||||
| Model 1: adjusted for sex, age, skin color and socioeconomic status | ||||||||
| Waist circumference, cm | Ref | − 1.65 | (− 2.98, − 0.31) | − 3.04 | (− 4.51, − 1.56) | − 3.83 | (− 5.20, − 2.46) | < 0.001 |
| Systolic BP, mmHg | Ref | − 1.04 | (− 2.29, 0.21) | − 0.75 | (− 2.05, 0.55) | − 1.16 | (− 2.70, 0.37) | 0.220 |
| Diastolic BP, mmHg | Ref | − 0.07 | (− 0.97, 0.84) | − 0.10 | (− 1.08, 0.88) | − 0.31 | (− 1.33, 0.71) | 0.586 |
| Mean BP, mmHg | Ref | − 0.39 | (− 1.33, 0.55) | − 0.32 | (− 1.35, 0.71) | − 0.60 | (− 1.72, 0.53) | 0.381 |
| Triglycerides (log)a, mg/dl | Ref | 0.001 | (− 0.05, 0.05) | − 0.03 | (− 0.07, 0.02) | − 0.07 | (− 0.12, − 0.02) | 0.002 |
| HDL-c, mg/dl | Ref | − 0.43 | (− 1.57, 0.71) | 1.34 | (0.15, 2.53) | 3.05 | (1.83, 4.26) | < 0.001 |
| Fasting plasma glucose, mg/dl | Ref | 0.16 | (− 0.65, 0.97) | − 0.10 | (− 0.84, 0.64) | − 0.43 | (− 1.46, 0.59) | 0.308 |
| MetS-z, z-score | Ref | − 0.16 | (− 0.45, 0.14) | − 0.55 | (− 0.86, − 0.24) | − 0.98 | (− 1.27, − 0.69) | < 0.001 |
| MetS-z without waist circumference, z-score | Ref | 0.22 | (− 0.25, 0.29) | − 0.22 | (− 0.49, 0.05) | − 0.57 | (− 0.82, − 0.32) | < 0.001 |
| Model 2: adjusted for variables in model 1 plus physical activity and skipping breakfast | ||||||||
| Waist circumference, cm | Ref | − 1.94 | (− 3.36, − 0.53) | − 3.28 | (− 4.84, − 1.73) | − 4.07 | (− 5.56, − 2.58) | < 0.001 |
| Systolic BP, mmHg | Ref | − 1.20 | (− 2.47, 0.07) | − 0.86 | (− 2.22, 0.51) | − 1.39 | (− 3.02, 0.24) | 0.165 |
| Diastolic BP, mmHg | Ref | − 0.17 | (− 1.13, 0.79) | − 0.09 | (− 1.09, 0.91) | − 0.48 | (− 1.56, 0.60) | 0.472 |
| Mean BP, mmHg | Ref | − 0.51 | (− 1.49, 0.47) | − 0.35 | (− 1.41, 0.72) | − 0.78 | (− 1.98, 0.41) | 0.293 |
| Triglycerides (log)a, mg/dl | Ref | − 0.01 | (− 0.06, 0.04) | − 0.04 | (− 0.09, 0.01) | − 0.08 | (− 0.12, − 0.0− 3) | 0.001 |
| HDL-c, mg/dl | Ref | − 0.23 | (− 1.40, 0.95) | 1.87 | (0.59, 3.15) | 3.02 | (1.77, 4.27) | < 0.001 |
| Fasting plasma glucose, mg/dl | Ref | − 0.05 | (− 0.92, 0.82) | − 0.44 | (− 1.28, 0.39) | − 0.62 | (− 1.65, 0.41) | 0.143 |
| MetS-z, z-score | Ref | − 0.29 | (− 0.60, 0.02) | − 0.71 | (− 1.06, − 0.37) | − 1.07 | (− 1.38, − 0.75) | < 0.001 |
| MetS-z without waist circumference, z-score | Ref | − 0.08 | (− 0.36, 0.19) | − 0.36 | (− 0.65, − 0.07) | − 0.63 | (− 0.88, − 0.38) | < 0.001 |
| Model 3: adjusted for variables in models 2 plus body mass index | ||||||||
| Waist circumference, cm | Ref | − 0.42 | (− 0.97, 0.14) | − 0.27 | (− 0.86, 0.31) | − 0.81 | (− 1.52, − 0.11) | 0.030 |
| Systolic BP, mmHg | Ref | − 0.28 | (− 0.58, 1.01) | 0.96 | (− 0.28, 2.20) | 0.59 | (− 0.78, 1.95) | 0.218 |
| Diastolic BP, mmHg | Ref | 0.23 | (− 0.72, 1.17) | 0.68 | (− 0.21, 1.57) | 0.37 | (− 0.62, 1.37) | 0.373 |
| Mean BP, mmHg | Ref | 0.05 | (− 0.92, 1.02) | 0.78 | (− 0.15, 1.71) | 0.44 | (− 0.61, 1.50) | 0.275 |
| Triglycerides (log)a, mg/dl | Ref | 0.001 | (− 0.50, 0.05) | − 0.01 | (− 0.06, 0.04) | − 0.04 | (− 0.09, 0.001) | 0.049 |
| HDL-c, mg/dl | Ref | − 0.60 | (− 1.79, 0.60) | 1.11 | (− 0.24, 2.46) | 2.22 | (0.98, 3.47) | < 0.001 |
| Fasting plasma glucose, mg/dl | Ref | 0.03 | (− 0.85, 0.91) | − 0.28 | (− 1.13, 0.58) | − 0.43 | (− 1.49, 0.63) | 0.318 |
| MetS-z, z-scorec | Ref | 0.02 | (− 0.25, 0.30) | − 0.10 | (− 0.38, 0.18) | − 0.40 | (− 0.66, − 0.14) | 0.005 |
| MetS-z without waist circumference, z-scorec | Ref | 0.10 | (− 0.20, 0.39) | − 0.04 | (− 0.33, 0.25) | − 0.28 | (− 0.53, − 0.03) | 0.031 |
BP, blood pressure; HDL-c, high density lipoprotein cholesterol; MetS-z, metabolic syndrome risk z-score
aTriglycerides was log transformed
bHighest values
cMean of MetS-z: − 0.05 (SE 0.09); mean of MetS-z without waist circumference: − 0.04 (SE 0.06), p for heterogeneity < 0.001