Table 1. The top 30 hub genes in PPI networks.
| Upregulated gene | Downregulated gene | ||
| Gene symbol | Degree | Gene symbol | Degree |
| TGFB1 | 94 | ALB | 28 |
| MMP9 | 78 | EGF | 10 |
| CXCL8 (IL8) | 75 | P4HB | 8 |
| ACTB | 70 | MAT1A | 6 |
| ITGB1 | 67 | GNMT | 6 |
| STAT1 | 65 | ABAT | 6 |
| TOP2A | 64 | CBS | 6 |
| ACTA2 | 58 | CTH | 6 |
| ICAM1 | 57 | PRSS3 | 5 |
| CDK1 | 57 | ECI2 | 5 |
| PTPRC | 56 | PLCB1 | 5 |
| ISG15 | 56 | ERP27 | 4 |
| OAS1 | 55 | PM20D1 | 4 |
| OAS2 | 53 | PRDX4 | 4 |
| FN1 | 52 | GCAT | 4 |
| CXCL10 | 52 | LPAR3 | 4 |
| OAS3 | 52 | CCKBR | 4 |
| COL1A1 | 51 | EPHX1 | 4 |
| CCNB1 | 47 | ACAT1 | 4 |
| SPP1 | 46 | ERO1LB | 4 |
| COL1A2 | 46 | GATM | 4 |
| ITGB5 | 45 | EPOR | 3 |
| ITGAM | 45 | GPT2 | 3 |
| ITGA2 | 43 | RNASE1 | 3 |
| NDC80 | 43 | PDIA2 | 3 |
| GBP1 | 42 | ANPEP | 3 |
| IRF9 | 41 | C5 | 3 |
| MX1 | 41 | AOX1 | 3 |
| TIMP1 | 41 | SDSL | 3 |
| HLA-A | 40 | CHRM3 | 3 |