Table 3. Association of the interaction between baseline and follow-up levels of circulating homocysteine and pathological complete response by treatment arm adjusted by tumor size and hormone receptors status.

	Odds ratio (95%CI)	p-value
Baseline homocysteine (w0)	1.135 (0.323–3.984)	0.843
Treatment arm	0.679 (0.234–1.967)	0.475
Homocysteine × treatment arm	0.976 (0.147–6.506)	0.980
Homocysteine w0 standard arm	0.950 (0.263–3.430)	0.937
Homocysteine w0 metformin arm	1.193 (0.265–5.373)	0.819
Follow-up homocysteine (w24-w0)	0.135 (0.009–1.983)	0.144
Treatment arm	1.400 (0.302–6.494)	0.668
Homocysteine × treatment arm	47.584 (1.604–1411.933)	0.026
Homocysteine w24-w0 standard arm	0.144 (0.010–2.077)	0.155
Homocysteine w24-w0 metformin arm	6.614 (0.822–53.189)	0.076