Table 1. Evidence for the involvement of Akt and Stat3 in cellular senescence.

Cells	Type of CS	Changes in activity/expression	Reference
IMR90 human lung fibroblasts	Replicative CS H2O2-induced CS	Increased Akt-1 and p-Akt-1 levels in senescent cells	[48]
Human vascular smooth muscle cells (VSMCs)	Replicative CS	Increased p-Akt level in senescent cells	[49]
EJ p53-null human bladder cancer cells	Replicative CS p53-induced CS	Increased p-Akt (pS473 and pT308) protein level in senescent cells	[46]
TIG3 human fibroblasts	Replicative CS IL-6-induced or soluble IL-6Rα- induced CS	Stat3 was constitutively activated in senescent cells (both with or without exogenous IL-6/ IL-6Rα stimulation)	[50]
Human umbilical vein endothelial cells (HUVECs)	TNFα-induced CS	Increased p-Stat1 and p-Stat3 levels in senescent cells	[51]
IPF-derived lung fibroblasts	Replicative CS	Hyperphosphorylation of Stat3 in IPF-derived lung fibroblasts with features of CS	[52]