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. 2019 May 21;12:761–770. doi: 10.2147/DMSO.S204439

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© 2019 Kunavisarut et al.

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Study protocol in type 2 diabetic patients who failed to maintain optimal glycemic control with a combination of maximum dosages of metformin and sulfonylurea (MFM-SUF group). Notes: After enrollment, the patients were standardized for lifestyle management and were assigned to continue the maximum daily dosage of the same sulfonylurea and the same dosages of metformin for 2 weeks, and then underwent the first OGTT, the Max-SU OGTT. After the Max-SU OGTT, the patients were assigned to discontinue their SU but continue taking the same dosages of metformin. After discontinuation of SU for 4 weeks, the second OGTT, the Discont-SU OGTT, was performed and then the same SU was restarted at 25% of the recommended maximum dose. After taking 25%Max-SU for 4 weeks, the third OGTT, the 25%Max-SU OGTT, was performed. Abbreviations: CBG, capillary blood glucose; OGTT, oral glucose tolerance test; SU, sulfonylurea.