Table 2.
Plasma glucose, insulin, Beta-cell function, insulin resistance indexes and mean fasting capillary blood glucose in the two groups during the OGTT
| Variable after 75 g OGTT | Max-SU (n=25) | Discont-SU (n=25) | 25%Max-SU (n=25) | NGT (n=28) | p-values (max-SU vs Discont-SU vs 25%Max-SU) | p-values (max-SU vs NGT) |
|---|---|---|---|---|---|---|
| Glucose 0 minutes (mmol/L) | 9.8±2.5* | 14.3±3.6** | 11.4±3.3*** | 4.9±0.4 | <0.0001 | <0.001 |
| Glucose 30 minutes (mmol/L) | 14.5±2.8* | 18.7±3.9** | 15.9±3.4 | 7.3±1.0 | <0.0001 | <0.001 |
| Glucose 60 minutes (mmol/L) | 18.1±3.0* | 22.6±3.8** | 19.5±3.3*** | 7.9±1.2 | <0.0001 | <0.001 |
| Glucose 90 minutes (mmol/L) | 20.4±2.9* | 25.2±4.4** | 22.3±3.5*** | 7.4±1.2 | <0.0001 | <0.001 |
| Glucose 120 minutes (mmol/L) | 20.6±3.0* | 25.9±4.4** | 22.2±3.5*** | 6.4±1.2 | <0.0001 | <0.001 |
| Insulin 0 minutes (pmol/L) | 146.1* (95.2, 261.1) | 126.1 (77.6, 176.6) | 135.4 (88.6, 196.1) | 45.8 (11.5, 93.4) | 0.04 | <0.001 |
| Insulin 30 minutes (pmol/L) | 30.47* (211.6, 369.3) | 158.3 (116.7, 217.9) | 202.5 (130.8, 328.3) | 300.4 (195.4, 373.3) | 0.04 | 0.139 |
| Insulin 60 minutes (pmol/L) | 239.5* (144.5, 372.3) | 165.0** (123.0, 252.0) | 226.0 (143.6, 304.5) | 340.3 (248.3, 496.6) | <0.0001 | 0.038 |
| Insulin 90 minutes (pmol/L) | 241.8* (181.9, 396.6) | 23.64 (164.2, 251.9) | 231.5*** (164.3, 282.2) | 350.7 (227.5, 541.7) | <0.0001 | 0.065 |
| Insulin 120 minutes (pmol/L) | 288.2* (181.1, 490.2) | 198.4** (140.8, 258.1) | 220.1 (146.8, 379.8) | 329.9 (170.9, 524.4) | <0.0001 | 0.514 |
| AUC Insulin0–120/Glucose0–120 | 0.10* (0.08, 0.17) | 0.06** (0.04, 0.09) | 0.09 (0.07, 0.12) | 0.34 (0.24, 0.44) | <0.001 | <0.001 |
| HOMA-IR | 7.84 (5.4, 15.87) | 11.65 (6.44, 16.70) | 10.15 (5.16, 13.45) | 1.39 (0.37, 2.83) | 0.179 | <0.001 |
| Matsuda index | 1.76 (0.92, 2.87) | 1.55 (1.08, 2.81) | 1.60 (1.23, 2.27) | 5.67 (3.67, 13.50) | 0.759 | <0.001 |
| Mean FCBG (mmol/L) | 10.3±2.4* | 14.2±3.7** | 12.3±3.4*** | N/A | <0.001 | N/A |
Notes: Data are shown as mean±SD or median (IQR). *Max-SU vs Discont-SU: p<0.05; **Discont-SU vs 25%Max-SU: p<0.05; ***Max-SU vs 25%Max-SU: p<0.05.
Abbreviations: Max-SU, during maximum dosage of sulfonylurea; Discont-SU, during discontinuation of sulfonylurea; 25%Max-SU, during dosage of 25% of the recommended maximum dosage of sulfonylurea; AUC, area under the curve; FCBG, fasting capillary blood glucose; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; OGTT, oral glucose tolerance test.