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. 2019 May 21;14:3723–3741. doi: 10.2147/IJN.S197990

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© 2019 Ahmed et al.

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Flow cytometry analysis of uptake of FITC-conjugated probes after 1h incubation, showing a significant 30% decrease in modified HSA probe uptake when MSR1 (SR-A1 gene) was silenced in THP-1 macrophages.

Notes: No significant decrease in modified HSA probe uptake was observed when CD36 and ORL1 (LOX-1 gene) receptor expression was silenced. The results shown are pooled data from two independent experiments (triplicate wells). Data are presented as mean fold change in FITC MFI and SD. **P<0.01, ****P≤0.0001 (ordinary one-way ANOVA and Dunnett’s multiple comparison test (siRNA compared with siNeg control)).

Abbreviations: HSA, human serum albumin; siNeg, siNegative; MFI, median fluorescence intensity.