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. 2019 May 21;14:3723–3741. doi: 10.2147/IJN.S197990

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© 2019 Ahmed et al.

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Flow cytometry analysis of FITC-conjugated probe uptake in relation to the addition of increasing concentrations of MDA-LDL (x=0.1 μM). MDA-LDL competed with Mal- and Aco-HSA for receptor-mediated uptake via SR-A1.

Notes: Addition of twice the concentration of MDA-LDL resulted in significant 40% and 53% decreases in the uptake of Mal-HSA and Aco-HSA, respectively compared with baseline (0.1 μM of modified HSA probe) after 1 h incubation. No significant competition was observed with oxLDL. The results shown are pooled data from two independent experiments (triplicate wells). Data are presented as mean FITC MFI and SD. *P<0.05, **P<0.01, ****P≤0.0001 (ordinary one-way ANOVA and Dunnett’s multiple comparison test). Each probe was analyzed separately.

Abbreviation: MFI, median fluorescence intensity.