Table 3.
Factors associated with age ≥ 70.
| Age < 70 (N=513) | Age ≥ 70 (N=92) | P value | |
|---|---|---|---|
| De novo Metastatic Disease | 0.4 | ||
| Yes | 129 (25.1) | 19 (20.7) | |
| No | 384 (74.9) | 73 (79.3) | |
| Prior Therapy for Metastatic | <0.0001 | ||
| None | 224 (43.7) | 59 (64.1) | |
| Hormonal | 106 (20.7) | 18 (19.6) | |
| Chemotherapy | 183 (35.7) | 15 (16.3) | |
| Early Dose Reductions | <0.05 | ||
| Yes | 107 (20.9) | 35 (38.0) | |
| No | 397 (77.4) | 55 (59.8) | |
| Late Dose Reductions | 0.6 | ||
| Yes | 88 (17.2) | 18 (19.6) | |
| No | 416 (81.1) | 72 (78.3) | |
| Number of Dose Reductions | <0.0001 | ||
| 0 | 330 (64.3) | 48 (52.2) | |
| 1 | 139 (27.1) | 23 (25.0) | |
| 2 | 41 (8.0) | 21 (22.8) | |
| Dose Delays | <0.0001 | ||
| Yes | 189 (36.8) | 52 (56.5) | |
| No | 324 (63.2) | 40 (43.5) | |
| Metastatic Line | <0.05 | ||
| Mean | 2.5 | 1.7 | |
| Median (range) | 2 (1–16) | 1 (1–6) | |
| Charlson Comorbidity Index | <0.0001 | ||
| Mean | 6.4 | 6.9 | |
| Toxicity | 0.3 | ||
| No | 405 (78.9) | 68 (73.9) | |
| Yes | 108 (21.1) | 24 (26.1) | |
| Heart Disease | <0.0001 | ||
| No | 487 (94.9) | 74 (80.4) | |
| Yes | 25 (4.9) | 17 (18.5) | |
| Kidney Disease | <0.0001 | ||
| No | 341 (66.5) | 32 (34.8) | |
| Yes | 172 (33.5) | 60 (65.2) |