Mouse primary lung fibroblasts (PLFs) were isolated from wild-type mice, and after passages 3–7, cells were treated with or without gp120 (10ng/mL). (A) At 24 and 72 hours, cells were harvested for α-SMA gene expression analysis by quantitative PCR. (B) At 72 hours, cells were harvested for α-SMA protein expression analysis by Western immunoblot. (A) Untreated PLFs at 24 and 72 hours N = 12 and 11, and gp120-treated PLFs at 24 and 72 hours N = 12 and 10. (B) Untreated and gp120-treated PLFs N = 12. *P<0.05 increased compared to untreated cells.