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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Am J Med Sci. 2019 Mar 22;357(6):483–491. doi: 10.1016/j.amjms.2019.03.006

Figure 7. Schematic representation of hypothesized effect of gp120 on mouse PLFs.

Figure 7.

The data present in this manuscript suggests that HIV-1 envelope protein gp120 binds to the cell surface receptor CXCR4 in the mouse primary lung fibroblast, resulting in activation of the CXCR4-ERK1/2 intracellular signaling cascade, and promoting fibroblast-to-myofibroblast transdifferentiation. This mechanism could explain the increase in fibrotic change seen in the lung of individuals infected with HIV as previously described by Crothers et al1.