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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Mass Spectrom Rev. 2018 Nov 25;38(3):265–290. doi: 10.1002/mas.21583

FIGURE 4.

FIGURE 4.

IMS profiles of glycan ions (A) [S1H5N4 + 3Na]3+ and (B) [S1F1H5N4 + 3Na]3+ glycans showing both conformational and intensity differences with respect to disease state. Note that in the case of S1H5N4, the disease states exhibit lower overall intensities than the healthy state, while S1F1H5N4 shows higher overall drift time intensities in the case of diseased states than in the healthy state. This might be due to increased fucosylation of glycans with cancer and cirrhosis. Reprinted with permission from Ref [J Proteome Res 2012, 11, 576–585] Copyright 2012 American Chemical Society.