Fig. 7.

Detailed XFM scans of NT2-N cells treated with cisplatin with and without addition of WR1065. a—cisplatin only; b—cisplatin and WR1065 co-treatment. Note the heterogeneity between cells and that cells with low K signal intensities the have highest Pt pixel intensities; the same cells have high Ca, Fe, Cu and Zn signals (most evident in cisplatin only—a). Scale bars are 20 microns, the color bar indicates that elemental concentrations for each element range from black pixels (no signal) to red pixels (highest signal for a given element). Concentration ranges are indicated above each element’s map, e.g., Pt concentration in a (cisplatin treatment) ranges from 0.000 µg/cm² (black pixels) to ≥ 0.218 µg/cm² (red pixels); in cisplatin-WR1065 treatment example (b), Pt signal goes from 0.016 µg/cm² (dark blue pixels) to ≥ 0.063 µg/cm² (red pixels). For mean elemental concentrations see Table 1. For a high detail scan of few cisplatin treated cells see Supplemental Fig. 3