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. 2019 Apr;22(4):384–390. doi: 10.22038/ijbms.2019.31788.7651

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of empagliflozin on collagen deposition (A) and PAS-positive material deposition (B) in renal tissues. A: Sections were stained by Masson's trichrome. B: Sections were stained by period acid Schiff. Pictures related to 20 randomly selected fields were analyzed using ImageJ software and the pixel intensities of the respective area were measured. The values in Diab and EMP groups were normalized by the values obtained for control rats. PAS, periodic acid-Schiff; Control, healthy control rats; Diab, diabetic control rats; EMP, diabetic rats treated with empagliflozin. ***P<0.01 vs Control group vs Diab rats