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. Author manuscript; available in PMC: 2019 May 26.
Published in final edited form as: Annu Rev Biochem. 2018 Jun 20;87:897–919. doi: 10.1146/annurev-biochem-060614-033910

Figure 7.

Figure 7

Likely activation intermediate observed in the A2aR. (a) Overlay of A2aR ( yellow; PDB 3PWH) and β2AR inactive ( gray; PDB 2RH1) states. (b) A2aR bound to agonist (orange; PDB 2YDV) superimposed on the antagonist-bound structure (PDB 3PWH) and the active structure bound to the mini-Gsα (magenta; PDB 5G53). (c) Overlay of A2aR (PDB 5G53) and β2AR ( green; PDB 3SN6) active states. Abbreviations: A2aR, adenosine 2a receptor; β2AR, β2-adrenergic receptor; Gsα, heterotrimeric G protein α subunit; PDB, Protein Data Bank.