Table 2:
Changes in outcomes between epochs for infants in hospitals with and without a SpO2 alarm policy change.
| Infants in hospitals with SpO2 alarm policy change (n=3809) | Infants in hospitals with no SpO2 alarm policy change (n=3685) | ||||||
|---|---|---|---|---|---|---|---|
| Outcome | Epoch 1 n=1981 | Epoch 2 n=1828 | aOR or Mean Difference (95% CI)* | Epoch 1 n=1620 | Epoch 2 n=2065 | aOR or Mean Difference (95% CI)* | Adjusted Interaction P-value |
| Mortality | 297/1979 (15.0%) | 324/1828 (17.7%) | 0.94 (0.75, 1.18) | 269/1615 (16.7%) | 280/2061 (13.6%) | 0.63 (0.50, 0.80) | 0.01 |
| Severe ROP | 127/1703 (7.5%) | 126/1535 (8.2%) | 1.09 (0.78, 1.52) | 88/1300 (6.8%) | 127/1746 (7.3%) | 0.91 (0.64, 1.29) | 0.46 |
| Necrotizing enterocolitis | 245/1980 (12.4%) | 250/1827 (13.7%) | 0.96 (0.78, 1.20) | 210/1620 (13.0%) | 250/2065 (12.1%) | 0.83 (0.67, 1.04) | 0.35 |
| BPD | 592/1722 (34.4%) | 700/1541 (45.4%) | 1.65 (1.36, 2.00) | 443/1343 (33.0%) | 794/1797 (44.2%) | 1.21 (0.99, 1.48) | 0.03 |
| Any ROP | 829/1703 (48.7%) | 655/1535 (42.7%) | 0.71 (0.59, 0.86) | 706/1300 (54.3%) | 935/1746 (53.6%) | 0.57 (0.47, 0.69) | 0.11 |
| Cumulative days on supplemental O2 (days), mean (SD)** | 43.5 (39.8) | 53.2 (42.5) | 3.87 (1.80, 5.94) | 39.5 (37.2) | 49.8 (40.3) | 1.70 (−.038, 3.79) | 0.14 |
| Discharged home on O2** | 161/1395 (11.5%) | 201/1113 (18.1%) | 1.47 (1.09, 1.99) | 223/1183 (18.9%) | 331/1357 (24.4%) | 1.12 (0.86, 1.45) | 0.17 |
Abbreviations: aOR: adjusted Odds Ratio; BPD: bronchopulmonary dysplasia; CI: confidence interval; ROP: retinopathy of prematurity; SD: standard deviation; SpO2: oxygen saturation
*
Analyses adjusted for gestational age, birth weight, multiple gestation, antenatal steroids, sex, race, ethnicity, delivery room intubation, small for gestational age status, and admission temperature
**
Among infants who survived to discharge