Table 3:
Change in supplemental oxygen exposure at specified time points between epochs for infants in hospitals with and without an oxygen saturation alarm policy change.
| Infants in hospitals with SpO2 alarm policy change (n=3809) | Infants in hospitals with no SpO2 alarm policy change (n=3685) | ||||||
|---|---|---|---|---|---|---|---|
| FiO2 >0.21 at time point | Epoch 1 n=1981 | Epoch 2 n=1828 | aOR (95% CI)* | Epoch 1 n=1620 | Epoch 2 n=2065 | aOR (95% CI)* | Adjusted Interaction P-value |
| 24 hours | 1193/1952 (61.1%) | 1199/1802 (66.5%) | 1.00 (0.85, 1.17) | 845/1582 (53.4%) | 1133/2031 (55.8%) | 1.08 (0.92, 1.27) | 0.475 |
| Day 3 | 1381/1923 (71.8%) | 1403/1788 (78.5%) | 1.15 (0.96, 1.39) | 1010/1553 (65.0%) | 1410/2020 (69.8%) | 1.17 (0.99, 1.40) | 0.881 |
| Day 7 | 1010/1835 (55.0%) | 1103/1718 (64.2%) | 1.16 (0.96, 1.40) | 694/1454 (47.7%) | 1061/1956 (54.2%) | 0.98 (0.81, 1.18) | 0.215 |
| Day 14 | 1005/1681 (59.8%) | 1131/1647 (68.7%) | 1.25 (1.01, 1.54) | 697/1313 (53.1%) | 1282/1889 (67.9%) | 1.60 (1.30, 1.96) | 0.096 |
| Day 28 | 878/1570 (55.9%) | 1042/1577 (66.1%) | 1.28 (1.04, 1.59) | 556/1165 (47.7%) | 1163/1819 (63.9%) | 1.68 (1.35, 2.09) | 0.083 |
| Across the first 28 days** | 1408/1767 (79.7%) | 1380/1593 (86.6%) | 1.29 (1.02, 1.63) | 1051/1416 (74.2%) | 1584/1850 (85.6%) | 1.79 (1.44, 2.23) | 0.045 |
Abbreviation: aOR: adjusted odds ratio; CI: confidence interval; FiO2: fraction of inspired oxygen; SpO2: oxygen saturation
*
Analyses adjusted for gestational age, birth weight, multiple gestation, antenatal steroids, sex, race, ethnicity, delivery room intubation, small for gestational age status, and admission temperature
**
among infants who survived to 28 days of life