FIGURE 3.

Hematoxylin and eosin (H&E)-stained kidney sections of streptozotocin-induced diabetic rats in different groups. A) In control group A (saline), the sections showed a severe distortion of the glomerular architecture, with atrophic and necrotic changes, pyknotic nuclei as well as infiltrations of mesangial spaces and interstitium. Many of the proximal and distal convoluted tubules showed hypertrophic cells and vacuolization. B) In group B (5 mg/kg CcAgNPs), there were moderate degenerative changes in the glomeruli. The mesangium and interstitium were essentially normal with cellular components. C) In group C (10 mg/kg CcAgNPs), the kidney sections showed glomeruli with Bowman’s space and capillary tufts, which appeared normal compared to controls. D) The kidney sections of diabetic rats in group D (200 mg/kg C. cassia extract) looked normal with clearly visible glomeruli, basement membrane of the capsular wall, and mesangial tissue. G: Glomerulus; DCT: Distal convoluted tubules; PCT: Proximal convoluted tubules; White arrow: Bowman’s space; Black arrow: Mesangial cells; Green arrow: Parietal layer; CcAgNPs: Cinnamomum cassia silver nanoparticles.