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. Author manuscript; available in PMC: 2019 May 26.
Published in final edited form as: Nat Med. 2018 Dec 6;24(12):1795–1803. doi: 10.1038/s41591-018-0271-8

Figure 3. Circadian regulation of tumor initiation and progression.

Figure 3

During tumorigenesis, several aspects of altered circadian control have been described at the stages of initiation and progression. These include genetic disruption of the canonical circadian transcriptional machinery and changes in epigenetic control mechanisms that regulate circadian gene expression, steps which are likely more implicated in tumor initiation. Subsequent deregulation of metabolism could further drive tumor progression, both in a cell autonomous manner and circadian metabolic changes that influence tumor/host interactions.