Table 3. HMP devices in the pre-clinical phase.

Device name	Animal studies	Human studies
Steen Heart Preservation System (Lund, Sweden)	Porcine DBD with 24 hours Non Ischaemic Hypothermic Perfusion (NIHP) followed by transplantation (26)	Heart transplantation using donor hearts preserved using NIHP (27); one successful clinical transplantation performed to date (28)
LifeCradle Heart Perfusion System Organ Transport System Inc, Frisco, TX, USA)	Porcine, non-DBD with 4 hours continuous perfusion followed by transplantation (29); Canine, DCD with 4 hours continuous perfusion followed by transplantation (30)	28 rejected or not offered donor hearts recovered using CSS, antegrade perfusion or retrograde perfusion for 12 hours followed by metabolic assessment (31)
HeartPort System (Modified Life Port System, Organ Recovery System, Itasca, IL, USA)	Porcine, non-DBD with 4 hours of continuous perfusion followed by Langendorff assessment for 60 minutes (32)
Paragonix Sherpa Perfusion™ Cardiac Transport System (Paragonix Technologies, Baintree, MA, USA)	Porcine, Non-DBD with 12 hours pulsatile perfusion followed by Langendorff assessment for 60 minutes (33)

HMP, hypothermic machine perfusion; DBD, donation after brain death; DCD, donation after circulatory death; CSS, cold static storage.