TABLE 1.

OP and OC AUC in plasma and ELF after NEB or i.v. administration of OP or OC^a

Treatmentb	AUC (μg/ml/h)
	AUCu,plasma,OP	AUCELF,OP	AUCu,plasma,OC	AUCELF,OC
i.v. OP	198	17,316	1,551	8,275
NEB OP	200	17,532	1,639	16,747
i.v. OC			2,810	5,626
NEB OC			2,842	3.77 × 106

^aAUC_u,plasma,OP values were calculated by multiplying the experimental data by the unbound fraction of OP (i.e., 0.58) (14).

^bFor i.v. OC and NEB OC, the AUC values were calculated by using the final model and data from Bedor et al. (1).