TABLE 2.
Parameter estimates of the best covariate modela
| Parameter | Value | % RSE | Bootstrap mean | Bootstrap 95% CI |
|---|---|---|---|---|
| θ1 (CL, male), liters/h | 1.99 | 6 | 1.98 | 1.75–2.23 |
| θ2 (CL, nonelderly female), liters/h | 2.13 | 6 | 2.13 | 1.87–2.38 |
| θ3 (CL, elderly female), liters/h | 1.44 | 10 | 1.45 | 1.17–1.71 |
| θ4 (V2), ml | 9,220 | 14 | 9,140 | 3,993–14,450 |
| θ5 (Q), ml/h | 22,200 | 4 | 22,190 | 20,252–24,092 |
| θ6 (V3), ml | 263,000 | 5 | 264,231 | 234,000–292,835 |
| θ7 (RA) | 0.664 | 6 | 0.661 | 0.574–0.735 |
| θ8 (GAM1) | 4.75 | 10 | 4.77 | 3.62–5.87 |
| θ9 (KAMAX), h−1 | 0.426 | 6 | 0.42 | 0.368–0.482 |
| θ10 V3 WTKG, Male | 0.0212 | 10 | 0.021 | 0.0141–0.028 |
| θ11 V3 WTKG, nonelderly female | 0.443 | 39 | 0.458 | 0.1–0.786 |
| θ12 V3 WTKG elderly female | 0.654 | 23 | 0.663 | 0.204–1.10 |
a
RSE, relative standard error; CI, confidence interval; CL, clearance; V2, volume of central peripheral compartment; V3, volume of peripheral compartment; Q, intercompartmental clearance; WTKG, body weight; GAM1, KAMAX, and RA, Weibull absorption parameters.