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. 2019 May 23;63(6):e00126-19. doi: 10.1128/AAC.00126-19

FIG 3.

FIG 3

MIC frequency of 19 P. aeruginosa clinical isolates (non-MBL producing and MBL producing) in incremental meropenem MICs in monotherapy and in combination therapy with fosfomycin and probability of target attainment of an fT>MIC of 40% for meropenem dosing regimens. (Left) 0.5-h infusion regimens; (right) 3-h infusion regimens. PTA, probability of target attainment; fT>MIC, the percentage of the time in a 24-h duration at which the free drug concentration remains above the MIC; CLCR, creatinine clearance; black bars, MICs for meropenem monotherapy; gray bars, MICs for meropenem combination therapy. The meropenem dosing regimens are represented by lines and symbols, as follows: for CLCRs of >50 ml/min, ●, 1 g q8h; ▲, 1.5 g q6h; ■, 2 g q8h; for CLCRs of >25 to 50 ml/min, ●, 1 g q12h; ▲, 1 g q6h; ■, 2 g q12h; for CLCRs of 10 to 25 ml/min, ●, 0.5 g q12h; ▲, 0.5 g q6h; ■, 1 g q12h; for CLCRs of <10 ml/min, ●, 0.5 g q24h; ▲, 0.5 g q12h; ■, 1 g q24h.