TABLE 4.

PTA surrogate índices for meropenem at fT_>MIC of 40% relative to MIC, duration of i.v. infusion (0.5 h and 3 h), and CL_CR

CLCR (ml/min)	Dose regimen	PTA (%) at the following MIC and infusion duration:
		0.5 μg/ml		1 μg/ml		2 μg/ml		4 μg/ml		8 μg/ml		16 μg/ml
		0.5 h	3 h	0.5 h	3 h	0.5 h	3 h	0.5 h	3 h	0.5 h	3 h	0.5 h	3 h
≥50	1 g q8h	99.5	99.8	99	99.4	97.8	98.7	94.9	96.5	85.2	88.9	61.6	66.6
	1.5 g q6h	99.9	100	99.8	100	99.6	99.9	98.9	99.5	96.4	97.2	87.8	90.7
	2 g q8h	99.8	99.9	99.6	99.8	99.2	99.4	97.8	98.5	94.8	95.9	85.3	88.4
25 to <50	1 g q12h	99.7	100	99.9	99.9	99.6	99.8	98.9	99.4	95.8	97.2	84.1	86.2
	1 g q6h	100	100	100	100	100	100	100	100	99.8	99.8	96.8	97.9
	2 g q12h	100	100	99.9	100	99.8	99.9	99.6	99.7	99	99.4	96.1	97.2
10 to <25	0.5 g q12h	100	100	100	100	100	100	99.8	99.9	98.3	98.6	84.4	85.2
	0.5 g q6h	100	100	100	100	100	100	100	100	100	99.9	97.1	97.1
	1 g q12h	100	100	100	100	100	100	100	100	99.8	99.8	98.4	98.6
<10	0.5 g q24h	100	100	100	100	100	100	100	100	99.9	100	96.8	99.9
	0.5 g q12h	100	100	100	100	100	100	100	100	100	100	99.5	99.4
	1 g q24h	100	100	100	100	100	100	100	100	100	100	99.9	100