TABLE 1.

Final experiment scheme for BALB/c and C3HeB/FeJ mouse models

Regimen by mouse straina	No. of miceb withdrawn from treatment for sacrifice (CFUs) or relapse assessmentc at the following time points:
	Week −6	Week −3	Week −2	Day 0	Week 4	Week 6		Week 8		Week 10		Week 12		Total
	CFUs	CFUs	CFUs	CFUs	CFUs	CFUs	Relapse	CFUs	Relapse	CFUs	Relapse	CFUs	Relapse
BALB/c mice
Untreatedd			9	9	9									27
RHZE					5	5		5		5		5	20	45
RHZEC					5	5		5		5	18	5	20	63
PHZE					5	5		5	18	5	18	5	20	81
PHZEC					5	5	18	5	18	5	18	5	20	99
Total			9	9	29	20	18	20	36	20	54	20	80	315
C3HeB/FeJ mice
Untreatedd ,e	12	12	16	12	12									64
RHZE					5	5		5		5		5	20	45
RHZEC					5	5		5		5	18	5	20	63
PHZE					5	5		5	18	5	18	5	20	81
PHZEC					5	5	18	5	18	5	18	5	20	99
Total	12	12	16	12	32	20	18	20	36	20	54	20	80	352

^aTreatment was initiated on day 0. Regimens were comprised of the following drugs and doses: R, rifampin 10 mg/kg; H, isoniazid 10 mg/kg; Z, pyrazinamide 150 mg/kg; E, ethambutol 100 mg/kg; C, clofazimine 12.5 mg/kg; and P, rifapentine 20 mg/kg.

^bAny discrepancies in the number of mice presented in this table and the number of mice from which data were obtained are accounted for in the supplemental raw CFU data tables associated with each mouse strain and time point.

^cRelapse was assessed 6 months after stopping treatment.

^dUntreated negative-control mice (three from each infection run) were followed after day 0 to verify M. tuberculosis virulence. Although included under the week 4 time point for simplicity, these mice were euthanized at various time points when they became moribund.

^eSixteen unassigned mice were moribund and euthanized after week −3 but before day 0; for simplicity, they are included in this table under the week −2 time point.