TABLE 2.
Relapse results determined 6 months after stopping treatment
| Regimen by mouse straina | Proportion (%) of mice with culture-positive relapse by treatment duration (weeks) |
|||
|---|---|---|---|---|
| 6 | 8 | 10 | 12 | |
| BALB/c mice | ||||
| RHZE | —b | — | — | 19/20 (95) |
| RHZEC | — | — | 10/18 (56) | 0/20 (0) |
| PHZE | — | 6/20 (30) | 1/18 (6) | 0/18 (0) |
| PHZEC | 5/18 (28) | 0/18 (0) | 2/18 (11) | 0/20 (0) |
| C3HeB/FeJ mice | ||||
| RHZE | — | — | — | 11/19 (58) |
| RHZEC | — | — | 7/17 (41) | 3/18 (17) |
| PHZE | — | 10/18 (56) | 0/17 (0) | 0/18 (0) |
| PHZEC | 5/17 (29) | 1/18 (6) | 1/18 (6) | 0/18 (0) |
a
Regimens are described in Table 1.
b
—, not determined.