TABLE 1.
In vitro antiviral activity of GRL-001-15 and GRL-003-15 against HIVNL4-3 and their cytotoxic profiles
| PI | EC50 (nM)a | CC50 (μM)a | Selectivity indexb |
|---|---|---|---|
| DRV | 4.1 ± 1.3 | 185 ± 8.4 | 45,121 |
| GRL-003-15 | 0.050 ± 0.025 | 11 ± 0.9 | 220,000 |
| GRL-001-15 | 0.057 ± 0.0024 | 38 ± 0.8 | 666,666 |
| GRL-121-13 | 0.17 ± 0.12 | 23 ± 2.9 | 135,294 |
| GRL-142-13 | 0.018 ± 0.0014 | 32 ± 1.6 | 1,777,777 |
a
All assays were conducted in duplicate, and the data shown represent mean values (±1 standard deviation) derived from the results of at least three independent experiments.
b
The selectivity index is the ratio of the CC50 to the EC50.