TABLE 2.

Percent probabilities of PK-PD target attainment by MIC and overall on day 1 based on the free-drug plasma %T>MIC target of 35% among simulated patients after administration of 1-g and 2-g ertapenem regimens

^aBased on the MIC distributions described in Table 3, 0.06, 0.12, 1, and >2 μg/ml were the MIC₉₀ values for E. coli, S. marcescens, Enterobacter spp., and K. pneumoniae, respectively.

^bShaded cells indicate percent probabilities of PK-PD target attainment of ≥90%. Values for individual genera represent the overall percent probability of PK-PD target attainment weighted over the ertapenem MIC distribution for each pathogen. Values for Enterobacteriaceae represent the overall percent probability of PK-PD target attainment for simulated patients with nosocomial pneumonia arising from Enterobacteriaceae based on the prevalence data for the four specified Enterobacteriaceae among patients with nosocomial pneumonia described in Table 4 and the associated ertapenem MIC distributions for these pathogens described in Table 3.