TABLE 2.
Individual empirical Bayesian post hoc parameter estimates stratified by agea
| Parameter | Median (range) |
|
|---|---|---|
| PNA < 14 days (n = 15) | PNA ≥ 14 days (n = 7) | |
| CL (liters/h) | 0.111 (0.061–0.549) | 0.311 (0.12–0.773) |
| CL (liters/h/kg) | 0.098 (0.055–0.223) | 0.244 (0.129–0.328) |
| CL (liters/h/70 kg) | 2.6 (1.4–5.4) | 6.7 (3.4–8.2) |
| V (liters) | 1.5 (0.712–4.3) | 1.2 (1–4.1) |
| V (liters/kg) | 1.1 (0.839–1.9) | 1.1 (0.676–1.4) |
| V (liters/kg/70 kg) | 77.8 (58.7–131.7) | 80 (47.3–97.6) |
| Half-life (h) | 7.1 (3–23.9) | 3.5 (1.9–6.5) |
a
PNA, postnatal age; CL, clearance; V, volume of distribution.