TABLE 2.
Modal MICs/MIC50s and MIC ranges for isavuconazole and comparators for the 429 mold isolatesh
| Isolate category | Total no. of isolates | Isavuconazole |
Voriconazole |
Itraconazole |
Posaconazole |
Amphotericin B |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Modal MIC/MIC50 (range) or MIC range (mg/liter) | % of isolates with MIC > 2 mg/liter | Modal MIC/MIC50 (range) or MIC range (mg/liter) | % of isolates with MIC > 1 mg/liter | Modal MIC/MIC50 (range) or MIC range (mg/liter) | % of isolates with MIC > 1 mg/liter | Modal MIC/MIC50(range) or MIC range (mg/liter) | % of isolates with MIC > 0.25 mg/liter | Modal MIC/MIC50 (range) or MIC range (mg/liter) | % of isolates with MIC > 1 mg/liter | ||
| All Aspergillus | 387 | 1/1 (≤0.125 to 16) | 8.9 | 1/1 (0.25 to 16) | 8.5 | 0.25/0.5 (≤0.125 to >16) | 9.8 | 0.125/0.125 (≤0.03 to >4) | 8.80 | 0.5/0.5 (0.03 to >4) | 3.1 |
| Most prevalent Aspergillus | |||||||||||
| A. flavus complex | 16 | 1/1 (0.5 to 4) | 6.3 | 1/1 (0.5 to 2) | 12.5 | 0.25/0.25 (≤0.125 to 0.5) | 0 | 0.125/0.125 (0.06 to 0.25) | 0 | 1/1 (0.5 to 4) | 18.8 |
| A. fumigatus | 322a | 1/1 (≤0.125 to 16) | 3.1 | 0.5/0.5 (0.25 to 16) | 4.0 | 0.25/0.25 (≤0.125 to >16) | 6.8 | 0.125/0.125 (≤0.03 to >4) | 6.2 | 0.5/0.5 (0.125 to 1) | 0 |
| A. nidulans complexb | 3 | 0.25 to 0.5 | 0/3 | 0.25 to 0.5 | 0/3 | ≤0.125 to 0.5 | 0/3 | 0.06 to 0.5 | 1/3 | 0.25 to 1 | 0/3 |
| A. niger complexc | 26 | 4/4 (1 to 16) | 65.4 | 1/1 (0.5 to 4) | 42.3 | 1/1 (0.25 to >16) | 38.5 | 0.25/0.25 (≤0.03 to 0.5) | 23.1 | 0.25/0.25 (0.03 to 0.5) | 0 |
| A. terreus | 12 | 2/1 (0.5 to 16) | 16.7 | 0.5/1 (0.5 to 8) | 25 | ≤0.125/0.25 (≤0.125 to >16) | 16.7 | 0.06/0.06 (≤0.03 to 0.5) | 16.7 | 1/1 (1 to 4) | 50 |
| Other Aspergillusd | 8 | 0.25 to 8 | 50 | 0.25 to 8 | 50 | ≤0.125 to >16 | 50 | 0.06 to >4 | 62.5 | 0.125 to >4 | 25 |
| Fusariume | 14 | (16 to >16) | 100 | (4 to >16) | 100 | (4 to >16) | 100 | >4 | 100 | 0.5 to >4 | 38.5 |
| Dermatophytesf | 9 | ≤0.125 to 2 | 0/9 | ≤0.125 to 1 | 0/9 | ≤0.125 to >16 | 3/9 | ≤0.03 to 0.5 | 2/9 | 0.25 to 1 | 0/8 |
| Mucoralesg | 16 | 0.25 to 16 | 62.5 | 8 to >16 | 100 | ≤0.125 to >16 | 60 | ≤0.03 to >4 | 68.8 | 0.03 to 2 | 6.3 |
A total of 232/322 A. fumigatus isolates were determined to be sensitive to itraconazole, posaconazole, and voriconazole by azole agar screening.
One isolate each of the A. nidulans complex, A. quadrilineatus, and A. spinulosporus.
Twenty-two A. niger complex, three A. tubingensis, and one A. luchuensis isolate.
Three A. calidoustus isolates and one isolate each of A. fischeri, A. giganteus, A. persii, A. similis, and A. turcosus.
Two F. dimerum, two F. proliferatum, seven F. solani sensu stricto, and three F. solani complex isolates.
Two M. canis, four T. rubrum, one T. interdigitale, and two T. mentagrophytes complex isolates.
Two M. circinelloides isolates, three R. pusillus isolates, four R. microsporus isolates, and one isolate each of C. muscae, L. corymbifera, L. ramosa, Lichtheimia species, R. oryzae, S. racemosum, and Mucorales species.
The proportions of isolates with MICs above the A. fumigatus EUCAST ECOFF are illustrated.