TABLE 4.

Modal MICs/MIC₅₀s and proportions of non-wild-type isolates for isavuconazole and comparators for the yeast isolates^e

Isolate category	Dilution range	Total no. of isolates	ISA		FLC		VRC		AMBa		ANF		MFG
			Modal MIC/MIC50 (range) or range (mg/liter)	% of non-WT isolates	Modal MIC/MIC50 (range) or range (mg/liter)	% of non-WT isolates	Modal MIC/MIC50 (range) or range (mg/liter)	% of non-WT isolates	Modal MIC/MIC50 (range) or range (mg/liter)	% of non-WT isolates	Modal MIC/MIC50 (range) or range (mg/liter)	% of non-WT isolates	Modal MIC/MIC50 (range) or range (mg/liter)	% of non-WT isolates
C. albicans	8	174	≤0.03/≤0.03 (≤0.03 to >4)	3.2	0.25/0.25 (≤0.125 to >16)	2.7	≤0.03/≤0.03 (≤0.03 to 2)	2.5	ND	0	≤0.008/≤0.008 (≤0.008 to 0.03)	0.3	≤0.008/≤0.008 (≤0.008 to 0.03)	3.2
	11	264	≤0.004/≤0.004 (≤0.004 to 4)		0.25/0.25 (0.03 to >32)		≤0.004/≤0.004 (≤0.004 to 2)		0.25/0.25 (≤0.016 to 0.5)		≤0.004/≤0.004 (≤0.004 to 0.125)		0.008/0.008 (≤0.004 to 0.5)
C. dubliniensis	8	24	≤0.03/≤0.03 (≤0.03)	5.3	≤0.125/≤0.125 (≤0.125 to 4)	5.3	≤0.03/≤0.03 (≤0.03)	5.3	ND	0	0.016/0.016 (≤0.008 to 0.5)	2.2	0.016/0.016 (≤0.008 to 1)	6.5
	11	33	≤0.004/≤0.004 (≤0.004 to >4)		0.125/0.25 (0.06 to >32)		0.008/0.008 (≤0.004 to >4)		0.03/0.03 (≤0.016 to 0.25)		0.008/0.008 (≤0.004 to 0.03)		0.016/0.016 (≤0.004 to 0.06)
C. glabrata	8	117	≤0.03/≤0.03 (≤0.03 to >4)	11.8	4/4 (0.5 to >16)	7.8d	0.06/0.06 (≤0.03 to 4)	7.8	ND	0	0.06/0.06 (0.016 to 1)	1.9	≤0.008/≤0.008 (≤0.008 to 1)	2.7
	11	205	0.06/0.06 (≤0.004 to >4)		4/4 (0.5 to >32)		0.06/0.06 (0.016 to >4)		0.25/0.25 (0.03 to 1)		0.016/0.016 (0.008 to 1)		0.016/0.016 (≤0.004 to 0.5)
C. krusei	8	15	0.125/0.125 (≤0.03 to 0.5)	1.9	>16/>16 (16 to >16)	0	0.25/0.25 (0.125 to 1)	1.9	ND	0	0.06/0.06 (0.03 to 0.06)	0	0.125/0.125 (0.06 to 0.25)	0
	11	39	0.125/0.125 (0.03 to 1)		32/32 (8 to >32)		0.25/0.25 (0.125 to 2)		0.5/0.5 (0.5 to 1)		0.03/0.03 (0.016 to 0.06)		0.125/0.125 (0.06 to 0.5)
C. parapsilosis	8	16	≤0.03/≤0.03 (≤0.03)	2.3	1/1 (≤0.125 to 4)	8.7	≤0.03/≤0.03 (≤0.03 to 0.06)	3.3	ND	0	>1/>1 (1 to >1)	0	(1/>1)/>1 (1 to >1)	0
	11	27	0.016/0.016 (≤0.004 to 0.25)		(0.5/1)/1 (0.5 to >32)		0.016/0.016 (0.008 to 2)		0.5/0.5 (0.125 to 1)		0.5/1 (0.5 to 2)		2/2 (0.5 to 4)
C. tropicalis	8	27	≤0.03/≤0.03 (≤0.03 to 0.125)	12.3	0.5/0.5 (≤0.125 to 16)	10.8	≤0.03/≤0.03 (≤0.03 to 0.25)	12.3	ND	0	0.03/0.03 (≤0.008 to 0.5)	1.0	0.016/0.016 (≤0.008 to 0.5)	1.0
	11	38	0.008/0.008 (≤0.004 to 2)		0.5/0.5 (0.125 to >32)		0.016/0.03 (0.008 to >4)		0.25/0.25 (0.125 to 1)		0.016/0.016 (≤0.004 to 0.03)		0.03/0.03 (≤0.004 to 0.06)
Other Candida speciesb	8	21	≤0.03 to 0.5		≤0.125 to >16		≤0.03 to 2				0.016 to >1		0.03 to 0.5
	11	39	≤0.004 to >4		0.06 to >32		≤0.004 to >4		0.06 to >4		≤0.004 to 2		0.016 to 0.5
Saccharomyces cerevisiae	8	5	≤0.03 to 1		2 to >16		0.06 to 0.5				0.06 to 0.25		0.125 to 0.25
	11	7	0.03 to 0.5		2 to 16		0.06 to 0.5		0.25/0.25 (0.06 to 1)		0.016 to 0.125		0.06 to 0.125
Cryptococcus neoformans	8	3	≤0.03 to 0.25		1 to 16		≤0.03 to 0.25				>1		>1
	11	7	0.008 to 0.125		2 to 16		0.016 to 0.125		0.25/0.25 (0.03 to 0.5)		>4		>4
All rare yeastc	8	3	0.125 to 0.5		8 to >16		0.06 to 2				>1		>1
	11	5	0.125 to 2		16 to >32		0.25 to >4		0.06 to 1		0.125 to >4		0.03 to >4

^aAmphotericin B was tested only in a wide concentration range.

^bFifteen C. lusitaniae isolates; 11 C. guilliermondii isolates; 6 C. orthopsilosis isolates; 5 C. kefyr isolates; 4 isolates of C. fermentati, C. inconspicua, and C. pelliculosa; 2 C. norvegensis isolates; and one isolate each of C. auris, C. bovina, C. duobushaemulonii, C. famata, C. metapsilosis, C. nivariensis, C. palmioleophila, C. pararugosa, and C. utilis.

^cTwo Geotrichum candidum and Rhodotorula mucilaginosa isolates and one isolate each of Arxula adeninivorans, Exophiala dermatitidis, Geotrichum silvicola, and Magnusiomyces capitatus.

^dPotentially an underestimate of the true non-wild-type proportion, as some of the C. glabrata isolates were not tested at fluconazole concentrations above 16 mg/liter.

^eISA, isavuconazole; FLC, fluconazole; VRC, voriconazole; AMB, amphotericin B; ANF, anidulafungin; MFG, micafungin; ND, not done.