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. 2019 May 23;63(6):e00073-19. doi: 10.1128/AAC.00073-19

TABLE 5.

Correlation between isavuconazole MICs and those of voriconazole, itraconazole, posaconazole, and amphotericin Ba

Species Voriconazole
 Itraconazole
 Posaconazole
 Fluconazole
 Amphotericin B
 No. of isolatesb
R2 P R2 P R2 P R2 P R2 P
A. flavus 0.598 0.0004 0.090 0.2581 0.196 0.086 ND ND 0.229 0.0608 16
A. fumigatus 0.766 <0.0001 0.289 <0.0001 0.071 0.0115 ND ND 0.003 0.6276 89
A. niger 0.573 <0.0001 0.537 0.0002 0.225 0.0177 ND ND 0.0414 0.3405 21–24
A. terreus 0.740 0.0003 0.763 0.0004 0.807 0.0002 ND ND 0.585 0.0038 10–12
Mucorales 0.381 0.0108 0.072 0.3336 0.691 <0.0001 ND ND 0.101 0.2291 15–16
C. albicans 0.896 <0.0001 ND ND ND ND 0.786 <0.0001 0.0215 0.4564 9–28
C. dubliniensis 0.938 0.0015 ND ND ND ND 0.857 0.008 0.675 0.0234 6–7
C. glabrata 0.862 <0.0001 ND ND ND ND 0.817 <0.0001 0.0092 0.1361 216–244
C. krusei 0.417 <0.0001 ND ND ND ND 0.207 0.0008 0.0146 0.3983 51
C. parapsilosis 0.448 0.0002 ND ND ND ND 0.00871 0.6573 0.0934 0.1289 25–26
C. tropicalis 0.786 <0.0001 ND ND ND ND 0.668 <0.0001 0.0679 0.1306 33–35
Other Candida 0.514 <0.0001 ND ND ND ND 0.439 <0.0001 0.000464 0.8845 42–48
a

The strongest correlation (highest R2 coefficient) for each species across the four comparators is highlighted in boldface type, and significant P values are underlined. ND, not done.

b

Number of paired values for comparison (isolates with MICs below the lowest concentration were excluded from analyses, whereas isolates with MICs above the concentration range were elevated to the nearest higher 2-fold dilution).