TABLE 2.
Pharmacokinetic parameters of olorofim in CD-1 mice
| Dose group | Cmax (ng/ml) | Cmin (ng/ml) | Tmax (h) | AUC0–8 (ng · h/ml) |
|---|---|---|---|---|
| 2.5 | 1,345 | 185 | 0.5 | 4,399 |
| 5 | 2,860 | 122 | 0.5 | 8,478 |
| 10 | 5,220 | 986 | 0.5 | 16,840 |
| 15 | 5,280 | 1,560 | 0.5 | 27,244 |
| 20 | 4,000 | 2,355 | 2 | 28,475 |
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