TABLE 1.

Antimicrobial activity of tested carbapenem agents against E. coli, K. pneumoniae, and P. mirabilis uropathogens^a

Antimicrobial agent by organism (no. of isolates)	No. (cumulative %) of isolates inhibited at MIC (mg/liter) of:											MIC50 (mg/liter)	MIC90 (mg/liter)
	≤0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	8	>8
E. coli (101)
Tebipenem	74 (73.3)	19 (92.1)	5 (97.0)	3 (100.0)								≤0.015	0.03
Meropenem	86 (85.1)	10 (95.0)	4 (99.0)	1 (100.0)								≤0.015	0.03
Doripenemb			98 (97.0)	2 (99.0)	1 (100.0)							≤0.06	≤0.06
Imipenemb			20 (19.8)	69 (88.1)	7 (95.0)	5 (100.0)						0.12	0.25
Ertapenem	86 (85.1)	5 (90.1)	1 (91.1)	5 (96.0)	1 (97.0)	3 (100.0)						≤0.015	0.03
K. pneumoniae (208)
Tebipenem	17 (8.2)	151 (80.8)	20 (90.4)	4 (92.3)	5 (94.7)	0 (94.7)	1 (95.2)	1 (95.7)	1 (96.2)	1 (96.6)	7 (100.0)	0.03	0.06
Meropenem	49 (23.6)	136 (88.9)	9 (93.3)	1 (93.8)	2 (94.7)	0 (94.7)	0 (94.7)	3 (96.2)	2 (97.1)	0 (97.1)	6 (100.0)	0.03	0.06
Doripenemb			182 (87.5)	11 (92.8)	4 (94.7)	0 (94.7)	0 (94.7)	2 (95.7)	1 (96.2)	3 (97.6)	5 (100.0)	≤0.06	0.12
Imipenemb		1 (0.5)	13 (6.7)	133 (70.7)	37 (88.5)	8 (92.3)	6 (95.2)	1 (95.7)	1 (96.2)	3 (97.6)	5 (100.0)	0.12	0.5
Ertapenem	153 (73.6)	13 (79.8)	13 (86.1)	7 (89.4)	5 (91.8)	0 (91.8)	3 (93.3)	2 (94.2)	1 (94.7)	1 (95.2)	10 (100.0)	≤0.015	0.25
P. mirabilis (103)
Tebipenem		15 (14.6)	48 (61.2)	35 (95.1)	4 (99.0)	1 (100.0)						0.06	0.12
Meropenem	1 (1.0)	17 (17.5)	63 (78.6)	17 (95.1)	5 (100.0)							0.06	0.12
Doripenemb			3 (2.9)	15 (17.5)	43 (59.2)	31 (89.3)	8 (97.1)	3 (100.0)				0.25	1
Imipenemb			1 (1.0)	6 (6.8)	14 (20.4)	17 (36.9)	52 (87.4)	11 (98.1)	2 (100.0)			1	2
Ertapenem	100 (97.1)	1 (98.1)	2 (100.0)									≤0.015	≤0.015

^aShading represents susceptible MIC values per CLSI 2018.

^bThe lowest concentration tested for doripenem and imipenem was 0.06 mg/liter.