TABLE 2.

Activity of tebipenem and comparator agents when tested against Enterobacteriaceae uropathogens

Antimicrobial agent by organism (no. of isolates)	MIC (mg/liter)			Susceptibility rates (%) according toa :
				CLSI			EUCAST
	50%	90%	Range	S	I	R	S	I	R
E. coli (101)
Tebipenem	≤0.015	0.03	≤0.015 to 0.12
Meropenem	≤0.015	0.03	≤0.015 to 0.12	100.0	0.0	0.0	100.0	0.0	0.0
Doripenem	≤0.06	≤0.06	≤0.06 to 0.25	100.0	0.0	0.0	100.0	0.0	0.0
Imipenem	0.12	0.25	0.06 to 0.5	100.0	0.0	0.0	100.0	0.0	0.0
Ertapenem	≤0.015	0.03	≤0.015 to 0.5	100.0	0.0	0.0	100.0	0.0	0.0
Amoxicillin-clavulanate	4	16	≤1 to 64	87.1	5.9	6.9	87.1		12.9b
							97.0		3.0c
Piperacillin-tazobactam	2	8	≤0.5 to 64	97.0	3.0	0.0	95.0	2.0	3.0
Cefazolin	4	>16	2 to >16	23.8	39.6	36.6d
				76.2		23.8e
Ceftriaxone	≤0.25	>64	≤0.25 to >64	79.2	0.0	20.8	79.2	0.0	20.8
Levofloxacin	≤0.03	>4	≤0.03 to >4	68.3	2.0	29.7	68.3	0.0	31.7
TMP-SMXf	≤0.25	>8	≤0.25 to >8	61.4		38.6	61.4	1.0	37.6
Fosfomycin	0.5	0.5	≤0.25 to >128	99.0	0.0	1.0	98.0		2.0
K. pneumoniae (208)
Tebipenem	0.03	0.06	≤0.015 to >32
Meropenem	0.03	0.06	≤0.015 to >32	94.7	1.4	3.8	96.2	1.0	2.9
Doripenem	≤0.06	0.12	≤0.06 to >8	94.7	1.0	4.3	94.7	1.0	4.3
Imipenem	0.12	0.5	0.03 to >32	95.2	0.5	4.3	95.7	1.9	2.4
Ertapenem	≤0.015	0.25	≤0.015 to >32	91.8	1.4	6.7	91.8	1.4	6.7
Amoxicillin-clavulanate	2	16	≤1 to >256	78.4	12.5	9.1	78.4		21.6b
							95.2		4.8c
Piperacillin-tazobactam	4	32	≤0.5 to >64	88.9	2.9	8.2	80.3	8.7	11.1
Cefazolin	4	>16	1 to >16	47.6	19.2	33.2d
				75.0		25.0e
Ceftriaxone	≤0.25	>64	≤0.25 to >64	76.0	0.0	24.0	76.0	0.0	24.0
Levofloxacin	0.06	>4	≤0.03 to >4	84.1	1.9	13.9	77.9	5.3	16.8
TMP-SMX	≤0.25	>8	≤0.25 to >8	72.1		27.9	72.1	1.0	26.9
P. mirabilis (103)
Tebipenem	0.06	0.12	0.03 to 0.5
Meropenem	0.06	0.12	≤0.015 to 0.25	100.0	0.0	0.0	100.0	0.0	0.0
Doripenem	0.25	1	≤0.06 to 2	97.1	2.9	0.0	97.1	2.9	0.0
Imipenem	1	2	0.06 to 4	87.4	10.7	1.9	98.1	1.9	0.0
Ertapenem	≤0.015	≤0.015	≤0.015 to 0.06	100.0	0.0	0.0	100.0	0.0	0.0
Amoxicillin-clavulanate	≤1	8	≤1 to 64	93.2	1.0	5.8	93.2		6.8b
							98.1		1.9c
Piperacillin-tazobactam	≤0.5	1	≤0.5 to 8	100.0	0.0	0.0	100.0	0.0	0.0
Cefazolin	8	>16	4 to >16	0.0	13.6	86.4d
				82.5		17.5e
Ceftriaxone	≤0.25	1	≤0.25 to >64	90.3	1.0	8.7	90.3	1.0	8.7
Levofloxacin	0.06	>4	≤0.03 to >4	83.5	2.9	13.6	70.9	9.7	19.4
TMP-SMX	≤0.25	>8	≤0.25 to >8	69.9		30.1	69.9	0.0	30.1

^aCriteria as published by CLSI 2018 and EUCAST 2018. S, susceptible; I, intermediate; R, resistant.

^bUsing other than uncomplicated UTI breakpoints.

^cUsing uncomplicated UTI breakpoints.

^dUsing parenteral, complicated UTI breakpoints.

^eUsing parenteral, uncomplicated UTI only breakpoints.

^fTMP-SMX, trimethoprim-sulfamethoxazole.