FIG 1.
(A) Alignment of the KPC160111 chromosome and chromosomes of representative KPC-producing CG258 strains, including SCKP020143 (NZ_CP028548.1; ST11, KL47), GD4 (NZ_CP025951.1; ST11, KL47), JM45 (NC_022082.1; ST11, KL125), HS11286 (CP003200.1; ST11, KL103), BR7 (CP018883.1; ST437), BR21 (NZ_CP018885.1; ST437), NJST258.1 (NZ_CP006923.1; ST258), and NJST258.2 (NZ_CP006918.1; ST258). Notable features, including prophages (11101 to 11110), integrated conjugative element ICEKpnHS11286.1, the CPS biosynthesis region for KL-47, the LPS biosynthesis region for OL101, and AMR genes, oqxAB, fosA, and blaSHV11, are indicated in the outer ring. Circular maps were generated using the BLAST Ring Image Generator (BRIG). (B) The blaKPC-2- and blaCTX-M-65-cocarrying plasmid pKPC-L111. Alignment of pKPC-L111 with three closely related plasmids, pKPHS2 (CP003224), pKPC-LK30 (KC405622), and pFDA444_2 (CP023942), generated using BRIG. Genes associated with resistance to antimicrobials and heavy metals are highlighted in red and green, respectively. (C) The blaOXA-48 plasmid pOXA48-L111. Alignment of pOXA48-L111 with the related plasmids, pKPoxa-48N1 (KC757416), pKp_Goe_765-2 (CP018461), pOXA-48 (JN626286), pOXA-48E1 (KP659188), and pRAY (KX524525), generated using BRIG. The blaOXA-48 gene is indicated in red.