FIG 2.
ZnLla has bactericidal activity and a low risk for resistance. (A) In vitro bactericidal activities of ZnLla, Lla, and ZnCl2 at different concentrations against H. pylori G27 (HP). Data represent medians ± standard deviation (SD) of the results from three independent experiments. (B) Development of resistance to ZnLla and metronidazole in G27. The fold change was the normalized ratio of the MIC obtained for a given subculture to the MIC that obtained for first-time exposure. Serial passaging of H. pylori with subinhibitory concentrations of metronidazole leads to high resistance against metronidazole. However, the development of resistance is not observed with ZnLla. Representative results from two independent experiments are shown.