TABLE 1.
Activity of MenA inhibitors against M. tuberculosis
| Compound | MIC (μM)a
|
||
|---|---|---|---|
| H37RvLP | H37RvMA | H37RvMA ΔcydC::aph | |
| NM-1 | 41 ± 2 | 55 ± 4 | 38 ± 3 |
| NM-2 | 42 ± 2 | 49 ± 2 | 43 ± 4 |
| NM-3 | 14 ± 0.2 | 15 ± 0.2 | 15 ± 2 |
| NM-4 | 4.5 ± 0.7 | 5.5 ± 1.7 | 3.8 ± 0.2 |
a
MenA inhibitors were tested against M. tuberculosis. MICs were calculated as the minimum concentrations required to inhibit the growth of M. tuberculosis by 90%, as determined by Levenberg-Marquardt least-squares plots. Data are the mean ± standard deviation of two independent experiments.