FIG 5.

In vivo antistaphylococcal PAE of CF-301 in the neutropenic mouse thigh infection model using MRSA strains MW2 (A) and CAIRD 426 (B). Dashed lines indicate strain-specific MIC levels. CF-301 serum concentrations are indicated by the red lines. Tissue burdens (CFU/g) for the untreated controls and the CF-301 treated animals are shown in green and purple, respectively. Black rectangles indicate the interval over which CF-301 serum levels exceed the MIC. Mean values are indicated ± standard deviations.