FIG 3.

Dose-normalized plasma concentration versus time by cohort. (Upper) Dose-normalized concentrations over the first 24 h for cohorts 1 to 11. (Middle) Dose-normalized concentrations over time for the single-dose cohorts 1 to 7. (Lower) Dose-normalized concentrations over time for the multiple-dose cohorts (8 to 11). Mean values (±SD) for each time point at each dosage level are represented by the symbols and bars above and below each symbol. (Milligram doses are represented in the graph. MD, multiple dose.)